45 Vasylkivska St., 03022, Kyiv, Ukraine
Phone: (044) 259 0183; fax:
(044) 258 1656;
e-mail: iepor@onconet.kiev.ua
The research is focused in four main areas:
– the study of cellular and molecular peculiarities of oncogenesis, aimed at developing methods of early diagnostics and a novel strategy of cancer therapy;
– the study of mechanisms of antitumor resistance and development of ways of recovery of defense systems of the organism;
– the study of the mechanisms of action of ionizing and non-ionizing irradiation and elaboration of methods to correct its effects at various levels of organization of the living systems;
– the study of adsorptive detoxication mechanisms, aimed at the creation of ‘artificial‘ organs.
The Institute of Experimental Pathology, Oncology and Radiobiology was organized back in 1960 by academician R. E. Kavetsky (1899-1978). Its academic traditions were based on the concept of organism-tumour interaction and gave an impetus to the formation of numerous science schools: ‘Tumor growth cytology’ (NAS academician V. G. Pinchuk); ‘Study of leukemogenesis mechanisms’ (NAS academician Z. A. Butenko); ‘Human cancer genetics’ (Prof. K. P. Ganina, Honoured Worker in Science and Engineering of Ukraine); ‘Biotherapy. Natural anticancer substances’ (NAS corresponding member D. G. Zatula); ‘Immunology of tumor growth’ (Prof. Yu. O. Umansky); ‘Basic mechanisms, means and methods of adsorptive detoxication therapy’ (Prof. V. G. Nikolayev, Honoured Worker in Science and Engineering of Ukraine).
Presently the Institute is a leading research centre for experimental and clinical oncology. It is headed by NAS corresponding member V. F. Chekhun.
Research into priority areas has allowed it to prepare for introduction various technologies aimed at early and differential diagnostics of tumoral pathology and a better efficiency of the treatment of malignant tumors of various localizations.
The role of hereditary factors in malignant tumor development has been determined and methodological recommendations for genetic advising worked out.
A panel of monoclonal antibodies for early and differential diagnostics of malignant tumors and leukemias has been created.
An anticancer vaccine for preventing relapses and metastases has been produced and registered in Ukraine (Certificate No 411/03-300200000 of December 9, 2003).
Methods to determine the individual sensitivity of malignant cells to antitumour drugs have been devised.
A novel method of photodynamic therapy of tumors has been developed on the basis of domestic photosensitizer.
A technology of absorptive detoxication in cancer patients has been developed.
An electronic version of reference-information system in pharmacotherapy of cancer patients has been produced. Not only does it permit the information on advanced approaches in cancer therapy to be received in compact and user-friendly form, but it can be regularly updated.